Biosynthesis of Psilocybin. Part II. Incorporation of Labelled Tryptamine Derivatives.
نویسندگان
چکیده
منابع مشابه
Biosynthesis of Psilocybin Part II*, Incorporation of Labelled Tryptamine Derivatives
The biosynthesis of psilocybin has been investigated by feeding labelled precursors to Psilocybe cubensis. The following specifically labelled compounds were synthesized: psilocin-H, 4hydroxytryptamine-, N,N-dimethyltryptamine-C and --H, N-methyltryptamine-C-H and DLtryptophan-H. A number of other indoles were labelled by acid catalyzed exchange in tritiated water. The experimental data suggest...
متن کاملpart a: application of n-(p-toluenesulfonyl) imidazole (tsim) and triphenylphosphine/carbon tetrachloride in several organic transformations part b: application of 8-bromocaffeine for synthesis of some novel 8-caffeinyl derivatives
بخش اول این پایان نامه به طور عمده بر توسعه کاربردهای جدید n-(پارا-تولوئن سولفونیل) ایمیدازول (tsim) و تری فنیل فسفین/ تتراکلرید کربن در تبدیل گروههای عاملی به یکدیگر استوار است. نظر به تنوع زیاد، دردسترس بودن، سمیت کمتر و نقل و انتقال آسان تر الکل ها نسبت به آلکیل هالیدها، تبدیل مستقیم گروه هیدروکسیل به گروه های عاملی دیگر مثل آزید، نیتریل و استر یکی از مهم ترین تبدیلات در سنتزهای آلی است. با ...
15 صفحه اولNeomycin biosynthesis: the incorporation of D-6-deoxy-glucose derivatives and variously labelled glucose into the 2-deoxystreptamine ring. Postulated involvement of 2-deoxyinosose synthase in the biosynthesis.
D-[6-3H3]6-Deoxy-5-ketoglucose (10) and D-[5,6-3H2]6-deoxyglucose (11) were incorporated into neomycins B and C using a growing culture of Streptomyces fradiae. D-[6-3H]6-Deoxy-5-ketoglucose was incorporated into neomycin, as efficiently as the well established precursor D-glucose, and was found to label exclusively the 2-deoxystreptamine ring of the antibiotic. The results strengthened the pre...
متن کاملBiosynthesis of aurodox (antibiotic X-5108). incorporation of 14C-labelled precursors into aurodox.
Streptomyces go/diniensis produces aurodox 3) (1) and small amounts of its N-demethyl homolog mocimycin (2)4) which is probably identical 5) with kirromycin 6,7). These antibiotics and a recently discovered disaccharide derivative of aurodox (3)8) are primarily active against Grampositive bacteria and enhance the growth of farm animals. The chemical structures, including stereochemistry, have b...
متن کاملBiosynthesis of ergothioneine by Claviceps purpurea. 3. The incorporation of labelled histidine.
common to both these compounds (Heath & Wildy, 1956a, b). These results indicated that this fungus forms ergothioneine by methylation and sulphuration of histidine. Subsequent work (Wildy & Heath, 1956, 1957) revealed that [2(ring)-14C]histamine would not serve as a precursor of the imidazole nucleus of either histidine or ergothioneine. Various metabolites of histamine, imidazoles possessing m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Chemica Scandinavica
سال: 1968
ISSN: 0904-213X
DOI: 10.3891/acta.chem.scand.22-1210